Wegovy®
A weekly GLP-1 treatment proven to reduce hunger and support meaningful, long-term fat loss.
- ~16.9% average body weight loss
- Boosts metabolic & cardiovascular health
- Proven, long-established safety profile
- Weekly injection, easy to use

Does your metabolism slow down when you sleep? Yes, metabolic rate decreases by approximately 5–10% during sleep compared to resting wakefulness—a normal physiological response as your body shifts into a restorative state. Whilst you burn fewer calories during sleep due to reduced physical activity and lower energy demands, your body continues performing essential functions including cellular repair, hormone regulation, and immune maintenance. This temporary metabolic slowdown is not detrimental to weight management; rather, quality sleep is crucial for long-term metabolic health, with chronic sleep deprivation significantly increasing risks of obesity, type 2 diabetes, and cardiovascular disease.
Summary: Metabolic rate decreases by approximately 5–10% during sleep compared to resting wakefulness, reflecting the body's shift into a restorative state with lower energy demands.
Your metabolism does indeed slow down during sleep, but this is a normal and essential physiological process rather than a cause for concern. Metabolic rate—the speed at which your body burns calories to maintain vital functions—decreases by approximately 5–10% during sleep compared to resting wakefulness. This reduction reflects the body's shift into a restorative state where energy demands are lower.
During sleep, your body continues to perform critical metabolic functions including cellular repair, hormone regulation, immune system maintenance, and memory consolidation. However, because you are not engaging in physical activity, digesting food, or maintaining full alertness, your energy expenditure naturally decreases. Your basal metabolic rate (BMR)—the calories needed for basic life-sustaining functions—remains active throughout the night, accounting for the majority of calories burned during sleep.
The metabolic slowdown varies across different sleep stages. During non-rapid eye movement (NREM) sleep, particularly deep sleep stages, metabolic rate reaches its lowest point. During rapid eye movement (REM) sleep, when dreaming occurs and brain activity increases, metabolic rate may increase compared with deep NREM sleep but typically remains at or below quiet wakefulness overall. This cyclical pattern repeats throughout the night as you progress through multiple sleep cycles.
It is important to understand that this metabolic reduction is not detrimental to weight management or overall health. In fact, adequate sleep supports healthy metabolism in the long term. The temporary decrease in metabolic rate during sleep is offset by the restorative processes that occur, which are essential for maintaining metabolic health during waking hours.
Several interconnected physiological mechanisms explain why metabolic rate decreases during sleep. The primary driver is the reduction in sympathetic nervous system activity—the 'fight or flight' response that keeps you alert and active during the day. As you transition into sleep, parasympathetic nervous system activity increases, promoting relaxation, lowering heart rate, and reducing blood pressure. These changes collectively decrease the body's energy requirements.
Core body temperature also drops during sleep, typically reaching its lowest point in the early morning hours. This thermoregulatory change is closely linked to metabolic rate, as maintaining body temperature requires significant energy expenditure. The reduction in core temperature during sleep corresponds with decreased caloric burn. This temperature decline is regulated by the suprachiasmatic nucleus in the hypothalamus, which coordinates circadian rhythms.
Hormonal changes further contribute to metabolic slowdown. Thyroid stimulating hormone (TSH) typically rises overnight, while circulating thyroid hormones show modest diurnal variation and likely play a minor role compared with reduced sympathetic tone, heart rate, and blood pressure. Additionally, cortisol levels drop to their lowest point during early sleep before rising towards morning. Cortisol influences glucose metabolism and energy mobilisation, so its nocturnal reduction contributes to decreased metabolic activity.
The absence of dietary thermogenesis—the energy required to digest, absorb, and process nutrients—also plays a role. During waking hours, eating accounts for approximately 10% of total energy expenditure. Since most people do not eat during sleep, this component of metabolism is absent. Furthermore, muscle activity is significantly reduced during sleep, particularly during REM sleep when temporary muscle paralysis (atonia) occurs to prevent acting out dreams, further lowering energy expenditure.

The relationship between sleep quality and metabolic health extends far beyond the temporary metabolic slowdown during sleep itself. Chronic sleep deprivation or poor sleep quality can significantly impair metabolic function, increasing the risk of obesity, type 2 diabetes, and cardiovascular disease. Research consistently demonstrates that adults who regularly sleep fewer than six hours per night have higher rates of metabolic dysfunction.
Poor sleep disrupts the balance of key metabolic hormones. Leptin, the hormone that signals satiety, decreases with insufficient sleep, whilst ghrelin, which stimulates appetite, increases. This hormonal imbalance can lead to increased hunger and cravings, particularly for high-calorie, carbohydrate-rich foods. Studies show that sleep-deprived individuals may consume additional calories compared to well-rested counterparts.
Insulin sensitivity—the body's ability to respond effectively to insulin and regulate blood glucose—can be impaired by poor sleep. Sleep restriction can reduce insulin sensitivity, potentially contributing to poorer glycaemic control. Over time, this may increase risk factors for type 2 diabetes. The mechanisms involve increased inflammation, elevated cortisol levels, and disrupted glucose metabolism.
Sleep disorders such as obstructive sleep apnoea (OSA) pose particular metabolic risks. OSA causes repeated breathing interruptions during sleep, leading to fragmented sleep and intermittent hypoxia (low oxygen levels). This condition is strongly associated with insulin resistance, hypertension, and dyslipidaemia. If you experience loud snoring, witnessed breathing pauses, or excessive daytime sleepiness, consult your GP, as OSA requires specific investigation and treatment. Treatment options include continuous positive airway pressure (CPAP) therapy for moderate to severe cases, or mandibular advancement devices for mild to moderate OSA. If you experience excessive daytime sleepiness that affects your driving, you should check DVLA guidance and seek medical advice.
Multiple factors influence how efficiently your metabolism functions during sleep, with significant individual variation. Age is a primary determinant—metabolic rate during sleep decreases progressively with advancing age, partly due to loss of muscle mass and changes in hormone production. Older adults typically burn fewer calories during sleep than younger individuals, even when accounting for body composition differences.
Body composition significantly impacts nocturnal metabolism. Muscle tissue is metabolically active even at rest, burning more calories than fat tissue. Individuals with higher muscle mass maintain a higher metabolic rate during sleep. This is one reason why resistance training and maintaining lean muscle mass are important for metabolic health. Conversely, higher body fat percentage, particularly visceral (abdominal) fat, is associated with metabolic dysfunction and may alter normal sleep-related metabolic patterns.
Sleep environment plays an often-overlooked role. Room temperature affects metabolic rate during sleep—sleeping in cooler environments (around 18°C) may slightly increase calorie burn as the body works to maintain core temperature. However, excessively cold or warm environments can disrupt sleep quality, which has more significant metabolic consequences than any minor calorie-burning advantage.
Meal timing influences nocturnal metabolism. Eating large meals close to bedtime can elevate metabolic rate during early sleep due to dietary thermogenesis, but this may also impair sleep quality. The body's ability to process glucose is reduced in the evening due to circadian rhythms, meaning late-night eating may contribute to poorer glycaemic control. Alcohol consumption before bed, whilst initially sedating, fragments sleep architecture and disrupts sleep quality, potentially affecting metabolic processes during the night.
Optimising sleep quality is one of the most effective strategies for supporting healthy metabolism. Most adults need 6–9 hours of sleep per night, according to the NHS. Establishing a consistent sleep schedule—going to bed and waking at the same time daily, including weekends—helps regulate circadian rhythms and optimise metabolic hormone secretion.
Sleep hygiene practices form the foundation of good sleep quality:
Create a sleep-conducive environment: Keep your bedroom dark, quiet, and cool (around 18°C)
Limit screen time: Avoid electronic devices for at least one hour before bed, as blue light suppresses melatonin production
Establish a relaxing bedtime routine: Activities such as reading, gentle stretching, or meditation signal to your body that sleep is approaching
Avoid stimulants: Limit caffeine intake after early afternoon and avoid nicotine close to bedtime
Be mindful of alcohol: Whilst it may help you fall asleep initially, alcohol significantly impairs sleep quality
Physical activity supports both sleep quality and metabolic health, but timing matters. Regular exercise improves sleep quality and insulin sensitivity, but vigorous exercise within three hours of bedtime may be stimulating for some individuals. Morning or afternoon exercise is generally optimal for promoting evening sleepiness.
When to seek medical advice: Contact your GP if you experience persistent difficulty falling or staying asleep, excessive daytime sleepiness, loud snoring with breathing pauses, or if poor sleep is affecting your daily functioning. These may indicate underlying sleep disorders requiring investigation. Additionally, if you have concerns about unexplained weight changes, persistent fatigue, or symptoms suggesting metabolic dysfunction (increased thirst, frequent urination, slow wound healing), seek medical assessment. NICE recommends assessing risk for type 2 diabetes using validated tools in adults at high risk (e.g., by age, BMI, waist circumference, family history, high-risk ethnicity, history of gestational diabetes). If high risk is identified, HbA1c or fasting glucose testing may be recommended.
Metabolic rate decreases by approximately 5–10% during sleep compared to resting wakefulness, with the lowest rate occurring during deep non-REM sleep stages.
No, chronic sleep deprivation impairs metabolic health by disrupting appetite hormones, reducing insulin sensitivity, and increasing risks of obesity and type 2 diabetes, outweighing any minor increase in waking calorie expenditure.
Consult your GP if you experience persistent sleep difficulties, excessive daytime sleepiness, loud snoring with breathing pauses, unexplained weight changes, or symptoms suggesting metabolic dysfunction such as increased thirst or frequent urination.
The health-related content published on this site is based on credible scientific sources and is periodically reviewed to ensure accuracy and relevance. Although we aim to reflect the most current medical knowledge, the material is meant for general education and awareness only.
The information on this site is not a substitute for professional medical advice. For any health concerns, please speak with a qualified medical professional. By using this information, you acknowledge responsibility for any decisions made and understand we are not liable for any consequences that may result.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.
Block quote
Ordered list
Unordered list
Bold text
Emphasis
Superscript
Subscript