TestoGel, a widely prescribed testosterone replacement therapy in the UK, does not require refrigeration and should be stored at room temperature below 25°C. Many patients initially wonder whether this topical gel needs cold storage, particularly if they are accustomed to refrigerating other hormone treatments. Understanding proper storage is essential to maintain the medication's effectiveness and ensure safe use. This article explains the correct storage conditions for TestoGel, what happens if it is stored incorrectly, and practical tips for keeping your medication safe whilst travelling, all in line with MHRA guidance and the product's Summary of Product Characteristics.

Does TestoGel Need Refrigeration?

TestoGel does not require refrigeration and should be stored at room temperature. This testosterone replacement therapy gel is formulated to remain stable under normal household conditions, making it convenient for daily use without the need for special cooling equipment.

The product should be kept below 25°C (77°F) and must not be frozen. This is typically achievable in most UK homes throughout the year. Refrigerating TestoGel is unnecessary and not recommended. The Medicines and Healthcare products Regulatory Agency (MHRA) approved formulation is designed specifically for ambient temperature storage, and the Summary of Product Characteristics (SmPC) for both TestoGel 50 mg sachets and TestoGel 16.2 mg/g pump confirms that refrigeration is not required.

Many patients initially wonder about refrigeration because they associate medicines with cold storage, particularly injectable treatments. However, topical testosterone preparations like TestoGel differ significantly from some other hormone therapies. The gel maintains the active ingredient's potency at room temperature for the duration of its shelf life, provided it remains in its original packaging and properly sealed.

It is worth noting that whilst refrigeration is not needed, TestoGel should be protected from temperature extremes. Store the product in the original carton to protect from light. Avoid storing in excessively hot environments—such as direct sunlight, near radiators, or in cars during summer—as this can compromise effectiveness. Similarly, freezing temperatures must be avoided. The key principle is maintaining consistent, moderate room temperature below 25°C to ensure the medication retains its therapeutic properties throughout its use.

How to Store TestoGel Correctly

Proper storage of TestoGel ensures the medication remains effective and safe throughout its shelf life. Store TestoGel in its original packaging in a cool, dry place away from direct heat sources and sunlight. A bedroom drawer, wardrobe shelf, or cool cupboard typically provides suitable conditions. Avoid storing in bathrooms, as humidity and temperature fluctuations can affect the product.

Key storage requirements include:

• Temperature: Keep below 25°C in a location with stable room temperature; do not freeze

• Light protection: Keep in the original carton to protect from light

• Moisture protection: Store in a dry environment away from humid areas such as bathrooms

• Original packaging: Retain sachets or pump bottles in their original carton with the patient information leaflet

• Child safety: Keep out of sight and reach of children and pets, preferably in a locked cabinet

• Separation from other items: Store away from food, beverages, and other medications to prevent accidental mix-ups

Once a sachet is opened, the contents should be used immediately and the sachet discarded. Do not attempt to save partial sachets for later use, as this increases contamination risk and may reduce efficacy. For the TestoGel 16.2 mg/g pump-bottle formulation, ensure the cap is securely replaced after each use to prevent the gel from drying out or becoming contaminated. Follow any in-use shelf-life guidance provided in the patient information leaflet for your specific product.

Check the expiry date regularly and do not use TestoGel beyond this date, even if it has been stored correctly. Expired medication may have reduced potency or altered chemical composition. If you notice any changes in the gel's appearance, consistency, or smell, do not use it and consult your pharmacist. The NHS advises returning unused or expired medicines to your local pharmacy for safe disposal rather than disposing of them in household waste or down the drain, as this helps protect the environment.

What Happens If TestoGel Is Stored Incorrectly

Incorrect storage of TestoGel can compromise both its effectiveness and safety, though the specific consequences depend on the nature and duration of improper storage. Exposure to excessive heat is the most common storage error and can lead to degradation of the active testosterone ingredient, potentially reducing the medication's therapeutic effect. If TestoGel has been stored above 25°C for extended periods—such as being left in a hot car or near a radiator—the gel may not deliver the intended dose of testosterone, which could result in suboptimal symptom control.

Physical changes to the gel may also occur with improper storage. Extreme temperatures can alter the gel's consistency, making it either too thick to spread easily or too liquid to apply effectively. Freezing must be avoided, as it can cause separation of the gel's components, rendering it unsuitable for use. If you notice the gel has changed colour, developed an unusual odour, or shows signs of separation or crystallisation, it should not be used.

Consistently poor storage practices—such as prolonged exposure to heat, freezing, or light—may lead to unpredictable testosterone absorption. This could potentially cause fluctuations in testosterone levels, affecting symptom management and potentially influencing monitoring blood tests that guide your treatment. The Summary of Product Characteristics advises storing below 25°C, not freezing, and keeping the product in the original carton to protect from light.

If you suspect your TestoGel has been stored incorrectly, do not simply continue using it. Contact your pharmacist for advice—they can assess whether the medication is likely still safe and effective or whether a replacement is needed. Your GP or endocrinologist should be informed if you have been using potentially compromised medication, as this may affect interpretation of your testosterone level monitoring and symptom response. Never attempt to 'test' questionable medication on yourself, as this could lead to inadequate treatment of your hypogonadism.

Travelling with TestoGel: Storage Tips

Travelling with TestoGel requires some planning to ensure the medication remains properly stored whilst maintaining your treatment schedule. For UK travel, pack TestoGel in your luggage, keeping it away from heat sources. If travelling by car during summer, avoid leaving medication in the vehicle, particularly in the boot or on the dashboard where temperatures can exceed safe storage limits. An insulated pouch (without ice packs, which could freeze the gel) can provide additional protection during hot weather.

For air travel, it is advisable to carry TestoGel in hand luggage to avoid temperature extremes and loss. Essential medicines, including those over 100 ml, may be carried in hand luggage if declared at security with supporting documentation. Carry a letter from your GP confirming your prescription, as this helps explain the medication to security personnel and customs officials. The letter should include your name, the medication name (including generic name: testosterone), dosage, and confirmation that it is medically necessary. Keep medication in its original packaging with pharmacy labels visible.

Testosterone is a Schedule 4 controlled drug under UK law. For international travel, check GOV.UK guidance on travelling with controlled drugs and research the regulations of your destination country, as some countries have restrictions on importing testosterone products. You may need additional documentation or permissions depending on your destination and the quantity you are carrying.

When travelling abroad, research the climate of your destination. In hot countries, store TestoGel in the coolest part of your accommodation—often the bedroom in a drawer away from windows and direct sunlight. Avoid leaving TestoGel in beach bags, cars, or other locations where temperatures may exceed 25°C. Hotel room safes, whilst secure, may not be climate-controlled and can become hot. Do not freeze the medication; avoid placing it near air-conditioning units that may cause freezing.

For extended trips, take sufficient supplies plus a few extra days' worth in case of travel delays. If travelling across time zones, maintain your usual application schedule based on your body clock initially, then gradually adjust if staying for extended periods. Should you have concerns about storage during travel or need advice about maintaining your treatment schedule, consult your GP or specialist before departure.

Frequently Asked Questions