Sulphur burps and diarrhoea are among the most commonly reported gastrointestinal side effects associated with retatrutide, an investigational triple receptor agonist currently in clinical trials. By activating GLP-1, GIP, and glucagon receptors simultaneously, retatrutide slows gastric emptying and alters gut motility — processes that can trigger foul-smelling burps and loose stools, particularly during dose escalation. This article explains why these symptoms occur, how frequently they are reported in trial data, and what practical dietary, lifestyle, and medical strategies may help manage them safely.
Summary: Sulphur burps and diarrhoea are common gastrointestinal side effects of retatrutide, caused primarily
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